huberman kyle gillett

Dr. Kyle Gillett

Dr. Kyle Gillett is a multifaceted professional with notable achievements in both medicine and therapy. He is a medical doctor who enjoys providing holistic and individualized care to his patients. His medical practice includes preventative medicine, sports medicine, hormone optimization, obstetrics and infertility, integrative medicine, and precision medicine including genomics. Dr. Gillett emphasizes the importance of treating the body, mind, and soul to achieve optimal health, advocating for shared decision-making and an evidence-based, patient-centered approach. He is actively involved in Obesity Medicine organizations and promotes the concepts of "food is medicine" and "exercise is medicine." Additionally, Dr. Gillett highlights the "6 pillars of health": exercise, diet, sleep, stress, sunlight, and spirit, considering them more powerful than any medication or supplement. He enjoys spending time outdoors with his family and engaging in various activities. In another aspect of his career, Dr. Gillett holds a Ph.D. in Marriage and Family Therapy from Texas Tech University and is a licensed Marriage and Family Therapist. He has over 20 years of experience in the field, including owning and operating residential treatment centers for adolescents, private practice work with couples and families, and contributions to Medical Family Therapy through presentations and publications. His clinical expertise is focused on helping individuals and families recover from psychological, emotional, and medical traumas. Dr. Gillett is trained in Brainspotting and Family Systems Theory, and he has founded numerous healthcare businesses. He values spending time with his family, engaging in various outdoor and recreational activities.

Male Hormone Optimization: Insights from Dr. Kyle Gillett and Andrew Huberman

Welcome to a deep dive into the fascinating world of male hormone optimization. This article, based on the first third of a podcast between Dr. Andrew Huberman, a neurobiology and ophthalmology professor at Stanford, and Dr. Kyle Gillett, a dual board-certified physician in family medicine and obesity medicine, explores the intricacies of male hormones and their impacts on various aspects of health and well-being.

Understanding Hormones and Their Impact

Dr. Kyle Gillett, with his expertise in hormone optimization, discusses the roles of key hormones like testosterone, dihydrotestosterone, estrogen, growth hormone, and thyroid hormone. These hormones play pivotal roles in mood, libido, strength, cognition, and psychological factors. This conversation specifically focuses on male hormone optimization, offering specific recommendations tailored to different ages and goals.

The Significance of Hormone Levels and Testing

A crucial aspect of hormone optimization is understanding the levels of hormones like testosterone. Dr. Gillett emphasizes the importance of regular hormone testing to gauge optimization. This includes assessing how one feels overall, which is often overlooked in health optimization discussions.

Hormone Optimization Across Different Ages

The podcast highlights the importance of considering hormone optimization at various life stages. From adolescence, puberty, and late teens to early adulthood and geriatric ages, hormonal changes impact men differently. This comprehensive approach benefits not only men but also offers insights for women and parents.

The Interaction Between Life Events and Hormones

Dr. Gillett and Dr. Huberman delve into the interplay between psychology, life events, and hormones. They explore how hormones influence our reactions to life events and vice versa, providing a broad yet detailed understanding of male hormone optimization.

The Role of Diet, Exercise, and Lifestyle in Hormone Function

A significant part of the discussion revolves around the behavioral foundations of optimal hormone function. Essential lifestyle factors like diet, exercise, and stress management play a crucial role in maintaining healthy hormone levels. This includes advice for different life stages, highlighting the importance of a balanced approach to diet, exercise, and other lifestyle choices.

Supplements and Prescription Drugs in Hormone Optimization

The conversation also touches upon supplement-based and prescription-drug-based tools for hormone optimization. These tools can be crucial in managing hormone levels, but they must be used judiciously and in the right context.

Exploring Supplement-based Tools for Hormone Optimization

In the continuing conversation between Dr. Andrew Huberman and Dr. Kyle Gillett, the focus shifts to supplement-based tools for hormone optimization. They discuss the benefits of supplements like creatine, betaine, l-carnitine, and others in supporting hormone function. Dr. Gillett emphasizes the importance of understanding the dosage and potential interactions of these supplements, highlighting their role in enhancing hormone profiles.

Hormone Interactions with Prescription Drugs

The podcast delves into the interaction between hormones and prescription drugs, particularly focusing on the role of l-carnitine and its effects on hormone receptors. Dr. Gillett provides insights into how different supplements can be used to manage hormone levels and improve overall health.

The Role of Vitamin D and Boron in Hormone Optimization

The importance of vitamin D, identified as a steroid hormone, in optimizing testosterone levels is discussed. Dr. Gillett also touches upon the role of boron in managing sex hormone-binding globulin (SHBG) levels, offering practical advice on dietary sources rich in boron.

Understanding Free Testosterone Levels and Genetic Factors

A significant part of the conversation revolves around understanding free testosterone levels and the genetic factors that influence these levels. The discussion includes insights into how various conditions like varicoceles can impact SHBG levels and, consequently, the percentage of free testosterone.

The Impact of Lifestyle Factors on Hormone Levels

Dr. Gillett and Dr. Huberman highlight the impact of lifestyle factors, such as diet, exercise, and stress management, on hormone levels. They explore the role of fasting in growth hormone optimization and discuss the importance of maintaining a balanced approach to lifestyle choices.

The Use of Peptides in Hormone Optimization

An in-depth discussion on the use of peptides in hormone optimization follows, with Dr. Gillett explaining the different types of peptides and their effects on growth hormone and IGF-1 levels. The conversation covers the potential benefits and risks associated with peptide use.

Testosterone Therapy and Its Implications

The podcast shifts to a detailed exploration of testosterone therapy, discussing the appropriate dosages, frequency of administration, and the potential side effects. Dr. Gillett provides insights into how testosterone therapy can affect various organ systems and emphasizes the need for close medical supervision.

Addressing Common Myths and Misconceptions

Dr. Gillett and Dr. Huberman address common myths and misconceptions related to hormone optimization. They discuss the effects of cannabis, nicotine, and alcohol on hormone levels and provide practical advice on managing these substances to maintain optimal hormone health.

Understanding Hair Loss and its Connection with Hormones

The final segment of the podcast between Dr. Andrew Huberman and Dr. Kyle Gillett delves into the topic of hair loss and its connection with hormones. They discuss the concept of miniaturization of hair follicles and the sensitivity of androgen receptors, highlighting the impact of hormones like DHT (dihydrotestosterone) on hair loss. Dr. Gillett explains the use of topical DHT receptor antagonists and other treatments to manage hair loss while maintaining hormone balance.

The Role of Caffeine and Other Topical Treatments in Hair Loss Prevention

Intriguingly, the conversation touches upon the role of topical treatments like caffeine and ketoconazole in preventing hair loss. Dr. Gillett clarifies the misconceptions around these treatments and their effectiveness in crowding out androgens at the scalp level.

The Impact of Turmeric and Curcuminoids on Hormone Levels

Dr. Gillett addresses questions about turmeric and curcuminoids, discussing their impact on DHT levels and overall hormonal balance. He elaborates on the beneficial actions of turmeric on the gut microbiome and the need to understand its systemic effects.

Examining the Effects of Phthalates and BPAs on Hormonal Health

The podcast also explores the effects of environmental factors like phthalates and BPAs on hormonal health. Dr. Gillett shares his personal approach to avoiding these substances and their potential to act as xenoestrogens, which can disrupt hormonal balance.

Recommendations on Prostate Health and Medications

The conversation shifts to prostate health, where Dr. Gillett discusses the use of medications like tadalafil for improving prostate health and blood flow. He provides recommendations on dosages and potential side effects, emphasizing the importance of medical supervision in hormone optimization.

Addressing the Role of Lifestyle and Diet in Hormonal Health

Throughout the podcast, Dr. Gillett and Dr. Huberman stress the significance of lifestyle and diet in maintaining hormonal health. They discuss the impact of alcohol, nicotine, and dietary fats on hormone levels, providing practical tips for optimizing these aspects of health.


This final segment of the podcast offers a comprehensive overview of advanced strategies for male hormone optimization, including the management of hair loss, the role of environmental factors, prostate health, and the importance of lifestyle choices. The discussion between Dr. Gillett and Dr. Huberman provides a wealth of knowledge for anyone interested in understanding and optimizing male hormones at a deeper level, concluding a highly informative and detailed series on male hormone optimization.